Sedating agents

This period of time is a "moving window" that accounts for drug intake during the four hours preceding any given moment.

Given large inter-patient variations, it is not feasible to predict an appropriate four-hour limit.

Pain scores of With inadequate analgesia the initial step should be an appropriate loading dose followed by an increase in the size of the PCA dose.

The recommended increase in dose size should be approximately 25%.

Continuous Infusion Examples: Patient utilizes 72 mg morphine over the preceding 12 hours Average hourly usage = 6 mg (72 mg 12 hours) Titration Titration of maintenance (PCA) dose is based on pain and sedation scores.

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