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A new formulation of depot medroxyprogesterone acetate (DMPA) for subcutaneous administration (DMPA‑SC 104 mg/0.65 ml, Sayana Press) was shown to be as effective as DMPA given by intramuscular administration (DMPA‑IM 150 mg/ml, Depo-Provera) for preventing pregnancy.

Bone mineral density (BMD) loss and weight gain were similar with both methods of administration.

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There were large individual variations in weight over 1 year, with some women losing and some women gaining more than 9 kg.